BeiGene (www.beigene.com)
is a 125+ person biotech company based in Zhong Guan Cun Life Science Park, Beijing. The company’s mission is to
discover and develop innovative drugs to serve the unmet medical needs in
China, Asia and worldwide area. The company is strived to build a vibrant,
dynamic research environment for creating better medicine and better life.
BeiGene has already completed an investment
from Merck and has collaborated with Janssen to in-license/co-develop two
clinical stage assets.
Below are listings for
positions that we are looking to fill in Biologics, Translational Medicine,
Oncology Biology, and Medicinal Chemistry. We are looking for passionate
truly exceptional people.
BeiGene's Biologics unit provides opportunities to
be exposed to full spectrum of preclinical research activities for
antibody-based biotherapeutics.
If
interested in any of the following job positions in Biologics
Unit, please send you resume/CV and cover letter to yucheng.li@beigene.com
Research
Investigator/Senior Research Investigator in Biologics-Cancer Biology
(Job code BLGC-001)
We are seeking experienced
scientists in cancer biology research and biologics (mAb)
drug discovery for cancer therapy.
The primary responsibilities
are to identify critical receptors, cell surface proteins and secreted proteins
for oncology drug development, to initiate and lead preclinical biologics
discovery project. The candidate will lead a group of 2-5 direct and/or
indirect reports to understand the biology of the therapeutic target, to
develop and validate cell-based assays and to investigate the mechanism of
action of the drug candidates in the setting of a fully integrated biotech
organization with a focus on delivery of high quality drug candidate. The
applicant is also expected to communicate effectively within project team and
company, as well as to external collaborators.
Requirements:
· PhD in cancer biology, cell
biology, biochemistry, pharmacology or molecular biology, with two or more
years of post doctoral training in cancer biology
research
· Skillful in dissecting a
complex scientific issue into smaller addressable questions, and designing
experiments to find the answers and solutions to the questions
· Expertise in ligand/receptor
biology, intracellular oncogenic signaling, hands-on experience in cancer biology
and receptor biology research, skillful in routine methods utilized for cancer
biology laboratory work such as siRNA/shRNA knock-down, mammalian cell transfection, immunoprecipitation, western blotting, flow cytometry
· Some experience in managing
scientist/research associate in a research organization
· Excellent analytical and
organizational skills
· Good oral and written communication skills in English
(knowledge in Chinese strongly preferred)
Research Investigator/Senior Research
Investigator in Biologics-Cancer Immunology
(Job
code BLGC-002)
We are
seeking experienced scientists in immunology and cancer immunology
research and biologics (mAb) drug discovery for
cancer therapy.
The
primary responsibilities are to identify cell surface receptors, proteins and
secreted proteins, ligands, whose activity may be modulated to elicit
activation of immune cells such as CD8+ cytotoxic lymphocytes, NK cells and
other immune cells attacking cancer. The candidate is expected to initiate and
lead preclinical biologics discovery project, and lead a group of 2-5 direct
and indirect reports to understand the biology of the therapeutic target, to
develop and validate cell-based assays and to investigate the mechanism of
action of the drug candidates in the setting of a fully integrated biotech
organization with a focus on delivery of high quality drug candidate. The
applicant is also expected to communicate effectively within project team and
company, as well as to external collaborators.
Requirements:
· PhD in immunology, and/or with
two or more years post doctoral training in cancer
immunology and immunology research
· Skillful in dissecting a
complex scientific issue into smaller addressable questions, and designing
experiments to find the answers and solutions to the questions
· Expertise in immune cell
ligand/receptor biology, immune cell regulation and interaction, intracellular
signaling, skillful in routine immunology lab methods and research such as
characterizing immune cells by FACS, isolating immune cells base on surface
markers, and assaying immune cell functions based on cytokine secretion, cell
proliferation and apoptosis, etc.
· Experienced in managing
scientist/research associate in an industrial organization
· Excellent analytical and organizational
skills
· Good oral and written
communication skills in English (knowledge in Chinese strongly preferred)
Senior
Research Investigator in Biologics-Protein Chemistry
(Job
code BLGC-003)
We are
seeking experienced and energetic individualsin
protein chemistry to support our biologics drug discovery for cancer therapy.
The
primary responsibilities are to express recombinant proteins, monoclonal
antibodies in mammalian cell lines and hybridoma
clones, purify proteins/mAbs to homogeneity from
conditioned medium or cell lysate, and perform analysis for the final purified
product. The scientist is expected to be well-organized, detail-oriented,
meeting pre-planned timeline for delivery of purified proteins and mAbs. The candidate will lead and work with a research
associate together to accomplish tasks with high standard of quality. The
candidate is also expected to communicate effectively with project teams and
evaluated new technologies for consistent improvement. An applicant with
extensive mAb experience and protein analytical skill
will be considered for higher position.
Requirements:
· PhD in biochemistry, molecular
biology or biology, with two or more years experience
working with protein purification and protein analyses
· Skillful in protein chemistry
problem-solving
· Expertise in protein and mAb affinity purification, column fractionation, endotoxin
control and removal, protein analytical techniques including Western blot,
concentration, endotoxin level, HPLC
· Experience in managing
scientists in a research organization, sound analytical and organizational
skills
· Good oral and written
communications skills in English (knowledge in Chinese strongly preferred)
Research
Investigator in Biologics-mAb Generation
(Job
code BLGC-005)
We are
seeking experienced scientist in monoclonal antibody generation to support
biological drug discovery effort for the treatment of cancer.
The
primary job functions are to generate mAbs by hybridoma fusion and cloning, to screen and identify mAbs binding to targetprotein by
ELISA assay, and to analyze mAb binding activity by
FACS. In addition, applicants with mAb phage display
experience have a significant plus for higher position. The candidate is
expected to present in the company internal meetings as well as to the external
collaborators。
Requirements:
· PhD or MS in biology, cell
biology or immunology, with two or more years of post-graduate training
experience in antibody technology and antibody generation
· Qualified to work with small
animals, such as mouse, rat and rabbit for immunization procedure, capable of
anatomic autopsy to remove spleen, lymph node for hybridoma
fusion
· Experienced in hybridoma cloning, cell culture, antibody screening and analyses
· Experience with medium to high
through put ELISA, and liquid handling ELISA system is highly appreciated
· Skillful in computer analytical
and presentation software such as Excel, Powerpoint,
and effective in oral communication
· For the consideration for higher
level position, knowledge in molecular biology and phage display technology are
required
Research
Investigator/Senior Research Investigator in Biologics- mAb
Humanization
(Job
code BLGC-007)
We are
seeking molecular biologists who are experienced in antibody technology and
engineering for biologics drug discovery.
The
primary responsibility is to support biologics research projects, which
includes designing and executing strategies for antibody humanization,
engineering, epitope-mapping and/or 3D structure analyses. The candidate will
be involved in performing binding assays such as ELISA, FACS and BiaCore SPR technology to characterize mAb
activity. The candidate will lead a group of 2-5 direct and/or indirect
reports to work with conscious timeline, meeting the project teams’
needs. The applicant is also expected to communicate effectively within
project team and company, as well as to external collaborators.
Requirements:
· PhD in molecular biology,
biochemistry or immunology with two or more years working in antibody
engineering field
· Skillful in solving technical
problems and barriers in protein and antibody engineering
· Experience in antibody
humanization, engineering and affinity maturation is highly appreciated
· Hands-on experience in
molecular biology lab work such as generation mutant protein expression constructs, transfection and expression,
mutation-structure-function analyses
· Experience in managing research
associates in a research organization
· Excellent analytical and organizational
skills
· Good oral and written
communications skills in English (knowledge in Chinese strongly preferred)
If you interested in following positions in Translational Biology and
Discovery Biomarker Unit, please contact eitherlai.wang@beigene.com or hr@beigene.com
Research Investigator in
Translational Biology and Discovery Biomarker
We are seeking leaders in translational biology
and discovery biomarker to support drug discovery efforts for the treatment of
cancer.
Theprimary responsibilities are to lead
a group of scientists to understand the mechanism of action of drug candidates,
to discover and validatenovel drug targets, and to
design biomarker strategy for pre-clinical and clinical compounds. BeiGene is a fully integrated biotech company with its
focus on translational research. This candidate is expected to present
and communicate internally and to collaborators. This candidate will also be
supervising a group of 1 to 2 research scientists.
Requirements:
·
Expertise
in cell biology, molecular biology, genetics and epigenetics.
·
Broad
knowledge of cancer biology
·
Demonstrated
ability to work collaboratively with peers across multiple areas of expertise
both inside and outside of BeiGene Bio
·
Demonstrated
scientific insight and problem solving, as evident in original research,
contribution to drug discovery, or senior authorship in publication or
invention.
·
Experience
in managing scientists in a research organization
·
Excellent
analytical and organizational skills
·
Excellent
communications skills – bilingual in English and Chinese
·
PhD
degree required
Principle Research
Investigator in Translational Biology and Discovery Biomarker
We are seeking leaders in translational biology
and discovery biomarker to support drug discovery efforts for the treatment of
cancer.
Theprimary responsibilities are to lead
a group of scientists to understand the mechanism of action of drug candidates,
to discover and validate novel drugtargets, and to
design biomarker strategy for pre-clinical and clinical compounds. BeiGene is a fully integrated biotech company with its focus
on translational research. This candidate is expected to present and
communicate internally and to collaborators. This candidate will also be
supervising a group of 2 to 5 research scientists.
Requirements:
·
Expertise
in cell biology, molecular biology, genetics and epigenetics.
·
Broad
knowledge of cancer biology
·
Demonstrated
ability to work collaboratively with peers across multiple areas of expertise
both inside and outside of BeiGene Bio
·
Demonstrated
scientific insight and problem solving, as evident in original research,
contribution to drug discovery, or senior authorship in publication or
invention.
·
Experience
in managing scientists in a research organization
·
Excellent
analytical and organizational skills
·
Excellent
communications skills – bilingual in English and Chinese
·
PhD
degree required
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Scientist / Principle
Scientist in Translational Biology and Discovery Biomarker
We are seeking highly motivated, experienced
individuals for the translationalbiology and
discovery biomarker team. The principle responsibilities will include handling
tissue samples, primary cell and cell line cultures, molecular cloning, genomic
and epigenetic analyses, RNA and protein profiling, and biomarker assay
development.
Qualified candidate will be responsible for
evaluating and presenting data to colleagues, and interacting with scientists
across disciplines.
Requirements:
·
BS/MS
degree in biology
·
Strong
expertise in molecular biology, cell biology, and/or biomarker assay
development
·
Strong
team-work spirit and communication kills
If you are interested in
following positions in Oncology Biology Group, please
contact Lusong.luo@beigene.com, orhr@beigene.com
Research Investigator in OncologyBiology (DB012)
We are seeking research investigator in the Oncology Biology
group to support drug discovery efforts for the treatment of cancer.
The primary responsibilities are to design and execute experiments to
understand the biology of the therapeutic target, develop and validate
cell-based assays and investigate the mechanism of action of the drug
candidates. This candidate is expected to present and communicate
internally and to collaborators. This candidate will also be supervising a
group of 2-5 research scientists.
Basic Qualifications
·
A Ph.D degree in Cell Biology, Molecular or Biochemistry in
oncology related field with 0-5 yearsexperience in
drug discovery
·
Experience
in cell based assay development in oncology
·
Excellent
analytical and organizational skills
·
Demonstration
of critical thinking skills as applied to experimental design and data
evaluation
·
Good
oral and written communications skills in English
Preferred Qualifications
· Experience in managing
scientists in a research organization
· Expertise in cell-assay
development (ELISA, MSD, AlphaLISA) and other molecular
/cell biology techniques including: plasmid construction, RNAi,
mammalian cell transfection, western blotting, flow cytometry,
immunoprecipitation
Communication ability in Chinese strongly
preferred.
About BeiGene
BeiGene is a fully integrated
biotechnology company based in Beijing that is focused on discovering and
developing innovative oncology drugs. Our compound portfolio will encompass
novel drugs that evolve out of our discovery laboratories in China and those
selected from in-licensing partners for their potential to have high impact in
the treatment of Chinese and Asian cancers.
To complement our discovery and
development capabilities, BeiGene is creating a
robust platform in China toenable the identification
of specific subsets of patient populations that will identify patients who are
most likely to benefit from the use of specific drugs or treatments.
Understanding the link between treatment sensitivity and molecular targets will
direct us to develop future drug candidates with greater efficacy and safety.
We are building core excellence
in:
•novel drug discovery in the
areas of both small molecules and biologicals
•translational research with an
emphasis on biomarker identification and validation in patients
•bioinformatics based on human
tumor genotyping and expression profiling
•clinical development
Weare
recruiting scientists who are passionate about research and innovation and who
have the entrepreneurial spirit to build a lasting organization in China known
for its impact on cancer.