https://careers.bms.com/jobs/R1564237?lang=en-us

Job Description

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us

The Oncogenesis Thematic Research Center (TRC) at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients.  The Oncogenesis TRC has a major focus of exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable. The group integrates discovery research through translational and early clinical development and exploits state-of -the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets and partners closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.

Position Responsibilities

This Senior Scientist level position will join the Discovery Biology team at the Oncogenesis TRC in San Diego, CA.  The qualified candidate should be a motivated and creative biologist who possesses substantial expertise in and passion for cancer biology and genetics, with a keen eye for novel therapeutic opportunities to address well defined patient populations. The individual will support and lead the discovery of novel targeted protein degradation drugs for solid tumor.  The successful candidate will be expected to work collaboratively in a multi-disciplinary environment to explore disease biology enabling identification of novel drug targets; develop and implement robust cellular assays to support discovery of small molecules as clinical development candidates; design and execute research strategies that further our understanding of the mechanisms of novel compounds and targets; and develop collaborations and interact with external partners relevant to the target discovery efforts. The desired candidate should have broad experience in cancer biology and in vitro cell culture techniques and a willingness to learn and adapt to any direction a project may take them. The candidate is expected to be able to work as an independent scientist, but also extensively collaborate or coordinate with other functional areas and contribute as part of a team to make project-based decisions. The successful candidate will demonstrate strong verbal and written communication skills, capable of presenting scientific results to multidisciplinary teams. This role is a primarily bench-facing cancer biology research position.

Key Responsibilities

• Based on literature and internal data, formulate mechanistic hypothesis for drug discovery projects and design and execute experiments to test these hypotheses

• Find, establish, and execute techniques or assays that are key for understanding mechanism of action of selected compounds/targets

• Develop new drug discovery projects based on literature and mining of existing data sets

• Utilize and develop multiple disease models to design target validation studies and relevant assays in support of SAR

• Collaborate with colleagues in other functional areas including informatics and translational research to generate testable hypotheses that will validate novel targets and solidify patient selection hypotheses

• Accurately maintain written reports and present results in an organized and timely manner

• Communicate effectively, foster teamwork and contribute to project strategy discussions

• Strong commitment to quality and demonstrate adaptability

Basic Qualifications:

• Bachelor’s Degree

  • 7+ years of academic and / or industry experience

Or

• Master’s Degree

  • 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 2+ of academic and / or industry experience

Preferred Qualifications:

• Ph.D. degree in cancer biology or related field with 3+ years of relevant academic or industry research experience in cancer biology, oncology target validation and/or drug discovery

• In-depth knowledge of molecular drivers of cancer

• Experience with preclinical models of solid tumors (2D and 3D spheroids and organoids, and cancer stem cells)

• Experience with CRISPR based technologies and cloning to interrogate targets and biological pathways

• Excellent oral and written communication skills, as well as the ability to effectively present scientific data and concepts to international standards

• Experience with targeted protein degradation technologies and molecular glue approaches is a plus

• A proven track record in the field of cancer biology/genetics, as evidenced by publication record

• Specific requirements:

  • Strong molecular and cell biology skillsets

  • Excellent capabilities in critical thinking and problem solving; able to independently design and efficiently execute experiments in the lab; capable of deliver high quality data in a timely manner

  • Cell culture, plate-based assays (eg CTG, annexin V), CRISPR, RNAi, cloning

  • Lentiviral expression, qPCR, western blotting, FACS, Immunofluorescence, live cell imaging

  • Windows, MS Office, graphing software (eg PRISM)

  • Capable of leading yet willing to support teams

  • Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills

#LI-Onsite

The starting compensation for this job is a range from $109,000-$150,700, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and the where the job is performed.

Final individual compensation will be decided based on demonstrated experience. 

For more on benefits, please visit our https://careers.bms.com/working-with-us.

Eligibility for specific benefits listed on our BMS Careers site may vary based on the job and location.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation.  Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment.  This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.