DESCRIPTION:
A project scientist position in computational biology is available to participate in a long-term project located within the San Diego Supercomputer Center and the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego (UCSD). Candidates will make vital contributions to establishing and subsequently using a computational platform to predict and understand protein functions at multi-scales through integrating data from structural genomics, functional genomics and chemical genomics. The project will combine tools derived from bioinformatics, chemoinformatics and biophysics. Features of the project include:
* Algorithm development for characterizing and analyzing functional sites and protein-ligand interactions.
* Genomics data mining and integration.
* Development of an ontology-driven protein-ligand interaction knowledge base.
* Evolution studied from the perspective of functional site conservation.
* Analysis of off-target binding by major pharmaceuticals.
QUALIFICATIONS:
* Ph.D. degree in biology, chemistry, computer science or a related scientific field, or comparable combinations of education and experience.
* Demonstrated experience with structural bioinformatics, sequence/structure analysis, homology modeling, and fold recognition.
* Experience with and knowledge of computational chemistry and chemoinformatics, protein-ligand docking, QSAR and pharmacophores.
* Demonstrated experience with developing scientific algorithms, statistics modeling and application of machine learning techniques.
* Demonstrated experience with Java and SQL programming.
* Effective oral and written communication skills and a proven ability to work effectively as a member of a team.
APPLICATION:
Send a CV and the names and emails of three references to Prof. Philip E. Bourne pbourne@ucsd.edu or Dr. Lei Xie lxie@sdsc.edu .
DESCRIPTION:
A scientific programmer position in bio- and chemo-informatics is available to participate in a long-term project located within the San Diego Supercomputer Center and the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego (UCSD). The individual will be responsible for independently implementing algorithms, developing web applications and designing a database system for use in bio- and chemoinformatics.
Features of the project include:
* Design, code, debug, and document software tools and web applications for analyzing large amounts of protein-ligand interaction data.
* Develop distributed multi-user editing tools for biological functional annotation.
* Ontology development in collaboration with domain scientists.
* Implement and integrate scientific algorithms with the Protein Data Bank (PDB) project by collaborating with the other members of the PDB at UCSD.
* Define user requirements and take direction by interacting with scientists in different disciplines.
QUALIFICATIONS:
* Advanced degree in Computer Science or a related scientific field, or comparable combinations of education and experience. M.S. or Ph.D. preferred.
* Demonstrated experience with Java, C, C++, Perl, Web Services, Web Applications, and the Semantic Web.
* Demonstrated experience with database management systems, object-relational mapping and data modeling techniques. Experience with and knowledge of OLAP technology strongly preferred.
* Demonstrated Experience with developing scientific visualization tools.
* Knowledge of biology and chemistry strongly preferred.
* Effective oral and written communication skills and a proven ability to work effectively as a member of a team.
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APPLICATION:
Send a resume and the names and emails of three references to Prof. Philip E. Bourne pbourne@ucsd.edu or Dr. Lei Xie lxie@sdsc.edu .