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Scientist II, LCMS

Status: Active
CompanyHD Biosciences
LocationSan Diego, CA
How to Apply

Please submit a copy of curriculum vitae to:

Job Summary:


Primarily responsible for developing and executing Liquid Chromatography Mass Spectrometry (LCMS) analysis and/or HTS Screening assays, the scientist will work closely with a diverse team of scientists to facilitate all aspects of running a HTS laboratory. 

Essential Job Functions:

  • Works on assignments with a diverse team of scientists to facilitate all aspects of performing high-throughput LCMS screening and running an HTS laboratory
  • Ability to run assays based on established protocols.
  • Performs preliminary lab work independently
  • Performs routine calculations, tabulates, and records results.
  • Assumes responsibility for technical accuracy of work.
  • Maintains, calibrates laboratory equipment and coordinates maintenance with vendors
  • Ability to instruct  Associate Scientists in the correct operation of the various liquid handlers and readers used in the laboratory
  • Develops new methods or assays based on minimal information or protocols.
  • Maintains research notebooks in a well-organized manner, ensures all necessary documentation is recorded.
  • Makes decisions based on an understanding of client program goals.
  • Communicates frequently with client and provide frequent update reports.
  • Makes logical suggestions of likely causes of problems and independently suggests solutions.
  • Ability to learn the use of semi-automated liquid dispensers, plate readers, and other lab instruments
  • Complies with all safety rules, practices good housekeeping, and maintains safe workplace without supervision.
  • Self-Motivated, requires minimal supervision and determines next steps with minimal guidance




Job Requirements:

Experience / Education

  • PhD + 3 or MS degree + 5 or BS degree + 7 years of experience in LCMS based assay development and biological sciences


Knowledge / Skills / Abilities:

  • Must possess skills in the following areas:
    • Solid understanding of qualitative and quantitative LCMS workflows in small molecule, lipidomics, glycomics and proteomics with associated sample preparation techniques
    • Solid competency in a broad range of LCMS instrumentation such as QQQ, QTOF and orbitrap and application solutions
    • Biophysical techniques such as SPR a plus
    • Biochemical and cell-based assay in high density plates a plus
  • Demonstrates competence in relevant technical aspects of scientific discipline which allows for increasing level of independence
  • Records experimental procedures and results in notebook
  • Demonstrates attention to details and concern for impact
  • Knowledge of commonly used concepts, practices, and procedures within biological R&D laboratory setting
  • Presents data clearly and concisely
  • Effectively communicates with others by giving and receiving feedback
  • Must work well with others in a team environment
  • Participates actively in meetings
  • Able to work in a fast paced environment
  • Well organized, detail oriented, and adaptable to changes
  • Excellent oral and written communication skills
  • Computer skills: knowledge of internet research, MS Word, Excel, Outlook, and PowerPoint.  Ability to learn instrument and data analysis software
  • Good time management and multi-tasking skills in order to complete multiple projects within timelines.
  • Ability to effectively prioritize workload and manage changes in direction
  • Ability to think critically and scientifically
  • Ability to search scientific literature and suggest protocols and methods
  • Regularly reviews goals and objectives with supervisor





Physical Requirements:

  • Must be able to work in an office environment with minimal noise conditions.


Must be able to work in Lab setting with exposure to Animals/biohazards/Chemicals 


  • Must not have animal allergies to applicable species in this facility 


  • Must be able to wear appropriate PPE


  • Must be able to work in environment with variable noise levels


  • Ability to stand /Sit/walk for long periods of time


  • Ability to Lift 10 lbs. routinely


  • Ability to crouch, bend, twist, and reach


  • Ability to push/pull 10 lbs. routinely/often / occasionally


  • Clarity of Vision


  • Ability to identify and distinguish colors


  • Must be able to perform activities with repetitive motions


  • Ability to climb Ladders / Stairs / Scaffolding


  • Ability to work in variable temperatures high to freezing



  • Inside/outside working conditions


An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability


This job description does not state or imply that the above are the only duties and responsibilities assigned to this position.  Employees holding this position will be required to perform any other job-related duties as requested by Management.

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