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Director, Translational Biology

Status: Archived
LocationSan Diego, California
How to Apply

Zentalis Pharmaceuticals is a San Diego based pharmaceutical company dedicated to the discovery and development of small molecule therapeutics targeting fundamental biological pathways of cancer. In the six years since our inception, we have successfully cleared four INDs with the FDA.  We believe our deep pipeline of oncology therapeutics has the potential to significantly improve the lives of patients with various types of cancer.



The ideal candidate has extensive experience in oncology drug discovery and development, leading projects in a matrix environment and managing reports. This person is capable of creating and implementing biomarker plans, investigating mechanism of action, preferred combinations as well as performing pharmacology assessment of drug action and PK/PD analysis for clinical candidates



  • Manages the work of multiple reports and leverages CROs and academic collaborators effectively to drive programs forward
  • Represents Translational Research in clinical stage teams
  • Contributes to the implementation and execution of strategies for choice of indication, potential patient selection and for identification of markers of early biological activity for preclinical projects working closely with Discovery Biology.
  • Drives the science of projects in clinical development including combination studies, expanding the scope of xenograft models to consider indications for clinical development, investigating the mechanism of action, potential mechanisms of resistance, and addressing questions arising from early clinical data
  • Creates and implements Translational Research plans for projects leading to first-in human clinical trials including selection of biomarkers, identification and validation of assays, writing biomarker sections of clinical protocols, engagement of CROs, implementation of assays, and interpretation of data
  • Develop translational datasets to drive recommendations on dose level and schedule for early phase clinical trials
  • Drives the development of potential Companion Diagnostic Assays in collaboration with the clinical, biostatistics and regulatory groups
  • Collaborates efficiently with clinical, legal, regulatory, bio-statistics and clinical operations groups across geographies
  • Manages external collaborations (academic and CROs)
  • Stays abreast of new technologies in the general area of Oncology research with emphasis on Translational Research
  • Contribute to drafting study reports, investigator brochure, patents, assay protocols, and peer-reviewed scientific publications
  • Presents complex biomarker and other relevant data to internal stakeholders and potentially conferences.



  • PhD, MD or MD/PhD in a scientific discipline plus at least 15 years of experience in oncology drug discovery and development, including in phase 1 and 2 clinical trials
  • In depth knowledge of cancer biology, in addition to in vitro and in vivo evaluation of cancer drugs
  • Significant experience in driving the science of projects as demonstrated by relevant publications
  • Experience managing reports
  • Strong background in technologies such as NGS, RNA seq, Immunohistochemistry, flow cytometry commonly used for biomarkers, and RNAi and/or CRISPR methodologies
  • Experience working with CROs and academic partners
  • Proficient in scientific software to analyze scientific and clinical datasets (e.g. Spotfire, Prism)
  • Able to communicate efficiently and to work productively in a matrix environment delivering results in a timely manner
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